Spider-Man has gone global! Parker Industries is more successful than ever, with offices in New York, Shanghai, London and San Francisco- and Peter Parker is racking up the frequent flyer miles with his "bodyguard" Spider-Man in tow, of course. But success breeds enemies and a reinvigorated Zodiac have also widened their scope to threaten the whole world. Join Dan Slott and Giuseppe Camuncoli as they take Spider-Man to the next level! This huge first issue also includes stories featuring Silk, Spidey 2099, Spider-Woman and much more!