Your favorite agents of S.H.I.E.L.D. in action across the Marvel Universe! Daisy Johnson — A.K.A. Skye, A.K.A. Quake — faces a seismic family reunion! Agent May and Mockingbird face an army of super-powered monstrosities! And — in a celebration of S.H.I.E.L.D.'s 50th anniversary featuring a never-before-printed art sequence by Jack Kirby and Jim Steranko — Phil Coulson and Nick Fury Sr. share a cross-time riddle: Who is the Man Called D.E.A.T.H.? Plus: S.H.I.E.L.D. recruits two charming new friends — Howard the Duck and Dominic Fortune! But when Earth falls to the Scarlet Centurion, Coulson and the gang have one chance to save it — by waging war on Asgard in the past!